Entry Fifteen: The Metamophosis

"...Grete! Grete!" she then shouted. "Mother?" called his sister from the other side.  They were communicating across Gregor's room. "You must go to the doctor's at once.  Gregor is sick.  Fetch the doctor fast.  Did you hear Grogor speaking just now?" "That was an animal's voice," said the chief clerk, noticeably quietly in contrast to the mother's shouting...And already the two girls were running down the hallway with rustling skirts-how had his sisters gotten dressed so quickly?-and tore open the apartment door. There was no sound of the door closing; they had most likely left it open, as is the case in apartments where a great misfortune has occurred.

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This is the moment the family realizes something is horribly wrong.  Hearing the voice of their brother and son as a monstrous vermin sends them over the edge. The sister's ability to get on task to help him so quickly testifies to the important role Grete will play in caring for Gregor as the story goes on.  Open doors usually invite people in with hospitality but in this case I think it is both a plea for anyone who can help to come in as well as an emergency exit route for the people in the apartment.